Yes. There are 2 ways to do so.
1. Using Salesforce authentication
Select Salesforce authentication from the authentication type drop-down,
then enter your username, select the org type (if you are not sure which org type you have please read this article first) and click Authorize.
On the login page, select Use Custom Domain
Enter your custom domain and select Continue to enter the username and password.
2. Using My Domain / Government Cloud
Select My Domain / Government Cloud from the authentication type drop-down, then enter your custom domain information and click Authorize.
For more information, see our guide on managing org connections in the app.